Struggling with scalp itchiness, flakes, or irritation? A good medicated shampoo for itchy scalp can provide real relief—fast.
Whether you're dealing with dandruff, seborrheic dermatitis, psoriasis, or general dryness, we've rounded up the top medicated formulas that calm the itch and restore scalp health.
Why Use a Medicated Shampoo for Itchy Scalp?
If your scalp constantly feels irritated, flaky, or inflamed, it could be caused by:
- Dandruff (Malassezia yeast overgrowth)
- Psoriasis or eczema
- Seborrheic dermatitis
- Product buildup or dryness
Medicated shampoos contain active ingredients like salicylic acid, ketoconazole, coal tar, and zinc pyrithione to treat the root cause—not just the symptoms.
Best Medicated Shampoos for Itchy Scalp in 2025
These are the top dermatologist-approved and highly rated shampoos designed to stop the scratch cycle.
1. Nizoral A-D Anti-Dandruff Shampoo
Best for Itchy Scalp Caused by Dandruff
- Contains 1% ketoconazole
- Kills dandruff-causing fungus
- Works even after rinsing
💬 “The only shampoo that stopped my itch and flakes within a few washes.”
2. Neutrogena T/Gel Therapeutic Shampoo
Best for Scalp Psoriasis & Chronic Dandruff
- Coal tar formula
- Clinically proven to reduce scalp irritation
- Long-lasting itch relief
💬 “My go-to for years—calms flare-ups quickly.”
3. Head & Shoulders Clinical Strength
🛒 Get Head & Shoulders Clinical
Best OTC for Daily Itch Relief
- 1% selenium sulfide
- Fights severe dandruff and seborrheic dermatitis
- Leaves hair soft and manageable
💬 “Affordable, effective, and easy to find. Works better than prescription for me.”
🛒 Get Head & Shoulders Clinical
4. Selsun Blue Medicated Maximum Strength
Best for Oily, Itchy Scalps
- Targets excess oil and fungal growth
- Selenium sulfide-based
- Helps reduce redness and scaling
💬 “Immediate relief and less greasy scalp after just two washes.”
5. DHS Zinc Shampoo
Best Zinc-Based Formula for Sensitive Scalps
- Contains 2% zinc pyrithione
- Gentle yet effective on inflamed scalps
- Fragrance-free, ideal for sensitive skin
💬 “No burning, no dryness—just calm, flake-free results.”
6. MG217 Medicated Conditioning Shampoo
Best for Psoriasis Relief
- Coal tar-based (3%)
- Treats itching, redness, and scaling
- Helps prevent flare-ups
💬 “Controls my scalp psoriasis better than anything else OTC.”
7. Derma E Scalp Relief Shampoo
Best Natural Medicated Option
- Contains salicylic acid + tea tree oil + aloe
- Soothes irritation without harsh chemicals
- Vegan, cruelty-free
💬 “Love the clean ingredients and it really helps my itchy scalp.”
8. CLn Healthy Scalp Shampoo
Best Dermatologist-Backed Choice for Itchy Scalp
- Developed by physicians
- Uses sodium hypochlorite to cleanse and reduce microbes
- Great for folliculitis and itchy scalp acne
💬 “Gentle but powerful—cleared my itchy bumps in a week.”
How to Use Medicated Shampoo for Best Results
✅ Use 2–3 times a week (unless directed otherwise)
✅ Let it sit on your scalp for 3–5 minutes before rinsing
✅ Follow with a moisturizing conditioner if your scalp feels dry
Final Thoughts
A quality medicated shampoo for itchy scalp can make all the difference—especially if you’re tired of scratching, flaking, or discomfort. Choose one that targets your specific condition and stick with it for consistent results.
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