Snakes on a Plane (2006)

An FBI agent takes on a plane full of deadly venomous snakes, deliberately released to kill a witness being flown from Honolulu to Los Angeles to testify against a mob boss.
 
Director:  David R. Ellis
Writers:  John Heffernan (screenplay), Sebastian Gutierrez 
Stars:   Samuel L. Jackson, Julianna Margulies, Nathan Phillips