Scientific Pocket Survival Guide - Vol.02 Pharmacokinetics

Scientific Pocket Survival Guide — Vol. 02: PHARMACOKINETICS — FROM DOSE TO EXPOSURE

What happens to a drug after it enters the body?

Scientific Pocket Survival Guide — Vol. 02: Pharmacokinetics follows the journey of a drug from administration to exposure, helping learners understand not only the key pharmacokinetic concepts, but also how to interpret concentration–time data and reason from evidence.

From absorption and distribution to metabolism, elimination, clearance and exposure, this volume builds a connected understanding of pharmacokinetics rather than presenting isolated definitions and equations.

Inside the guide

📥 Getting In

Absorption • Bioavailability • First-pass effect • Food • Formulation • Transporters

🧭 Getting Around

Distribution • Volume of distribution • Protein binding • Barriers • Redistribution

⚗️ Being Transformed

Phase I • Phase II • Metabolites • Enzyme inhibition & induction • Enterohepatic recirculation

🚪 Getting Out

Renal filtration • Secretion • Reabsorption • Renal clearance • Hepatic clearance • Total clearance

📈 The Curve Lab

Cmax • Tmax • AUC • Clearance • Half-life • Steady state • Dosing intervals

🧮 Modelling the Body

One- and two-compartment models • NCA • Compartmental analysis • Population PK • PBPK

🩺 When PK Meets Real Life

Drug interactions • Renal impairment • Hepatic impairment • Paediatric & geriatric PK • TDM • Modified-release formulations

🧠 PK Reasoning Lab

Data interpretation • Parameter Detective • Interaction Detective • Integrated Patient Case • PK Escape Room

🎯 Survival Vault

Master PK Map • Active Recall • Final Exam • Scientific References

More than a pharmacokinetics summary

The central principle of the volume is:

OBSERVATION ≠ EXPLANATION.

A changed concentration–time profile is something to interpret, not a mechanism to assume.

Throughout the guide, learners are encouraged to:

READ → INTERPRET → EXPLAIN → JUSTIFY → MONITOR

The volume combines illustrated explanations, scientifically grounded equations, concentration–time profiles, clinical reasoning, synthetic data exercises, interactive puzzles, case-based learning and retrieval activities.

📘 Scientific Pocket Survival Guide — Vol. 02

Pharmacokinetics: From Dose to Exposure

Illustrated • Evidence-informed • Student-focused