SAMN03317420_Khanty_2 23andme format

In this video, we analyze the ancient and modern genetic breakdown of a historic Khanty genome, originally published in 2015 from a sample gathered in the isolated village of Kazym—located 200 miles south of the Arctic Circle in the Khanty-Mansi Autonomous Okrug. Using advanced archaeogenetic tools and my custom andreimix mapper utility, we explore how this individual plots in relation to both West Eurasian and Siberian populations, revealing her unique positioning as a near-perfect genetic blend.

We dive deep into a multi-layered genetic analysis, starting with a Mesolithic breakdown and a Bronze Age model that uncovers a surprising amount of Proto-Iranic (Indo-European) admixture. We also review an F2-statistics analysis computed with qp-fstats to pinpoint her closest genetic relatives, from the neighboring Mansi and Siberian Tatars to the Bashkirs and Udmurt.

Finally, we run her genomic data through my DNA trait predictor to reconstruct her physical appearance—including eye color, hair texture, skin tone, and facial features—and examine a comprehensive health profile. We explore her polygenic risk scores for complex conditions like bipolar disorder, schizophrenia, and macular degeneration, alongside fascinating behavioral and metabolic traits ranging from dopamine reuptake genotypes (COMT/DRD2) to alcohol withdrawal risk and lactose intolerance.