Methods in Enzymology. Macromolecular Crystallography. Vol. 277. Part B
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Macromolecular crystallography is an indispensable component of enzymology.
Structural biology, with macromolecular crystallography as its central
technique, makes fundamental contributions to enzymology: one can
pose few enzymological questions without first checking to see what relevant
structures may be in the Protein Data Bank. Only then can one go on to
learn what it implies about the mechanism, what suggestions it makes for
genetic variation, and so on.
The chapters in these volumes present expert witness to the state-ofthe-
art for many individual aspects of the field. The two volumes provide
the logical train of objectives necessary to solve, refine, and analyze a
macromolecular crystal structure. Although these volumes may not serve
as a simple textbook to introduce the field, individual chapters should
provide a comprehensive background for each topic. Students and teachers
alike will benefit from a careful reading of each chapter as it becomes
relevant in the course of research.
Part A (Volume 276) deals with the three requisites for structure solution:
crystals, data, and phases. The first section covers aspects of the theory
and practice of growing high-quality crystals.
The presented Part B (Volume 277) continues the section on horizon methods for
phase determination. It follows with various ways in which structures are
built, refined, and analyzed.
eBook features:
Highlight, take notes, and search in the book
Page numbers coincide with the physical edition
Length: 664 pages
Structural biology, with macromolecular crystallography as its central
technique, makes fundamental contributions to enzymology: one can
pose few enzymological questions without first checking to see what relevant
structures may be in the Protein Data Bank. Only then can one go on to
learn what it implies about the mechanism, what suggestions it makes for
genetic variation, and so on.
The chapters in these volumes present expert witness to the state-ofthe-
art for many individual aspects of the field. The two volumes provide
the logical train of objectives necessary to solve, refine, and analyze a
macromolecular crystal structure. Although these volumes may not serve
as a simple textbook to introduce the field, individual chapters should
provide a comprehensive background for each topic. Students and teachers
alike will benefit from a careful reading of each chapter as it becomes
relevant in the course of research.
Part A (Volume 276) deals with the three requisites for structure solution:
crystals, data, and phases. The first section covers aspects of the theory
and practice of growing high-quality crystals.
The presented Part B (Volume 277) continues the section on horizon methods for
phase determination. It follows with various ways in which structures are
built, refined, and analyzed.
eBook features:
Highlight, take notes, and search in the book
Page numbers coincide with the physical edition
Length: 664 pages