Molecular Mechanisms of Breast Cancer: A Comprehensive Analysis of Nucleotide Composition, DNA Damage, and Immune Surveillance

This monograph provides a comprehensive, systematic analysis of the molecular mechanisms underlying breast cancer. It integrates three levels of investigation: (1) quantitative analysis of nucleotide composition and dinucleotide frequencies in the DNA of the 17th chromosome of breast cancer; (2) theoretical analysis of the role of ionizing radiation in DNA damage and the formation of abnormal DNA structures; and (3) immunological analysis of the mechanisms of immune surveillance and the failure of T cells to recognize and eliminate cancer cells. The work is based on a series of studies conducted using Python 3.14 for sequence analysis, and builds upon the theoretical framework of DNA repair mechanisms (Lindahl, Sancar, Modrich) and the role of the immune system in cancer (Allison, Honjo). The goal is to provide a unified, evidence-based model of breast cancer pathogenesis — from the initial radiation-induced DNA damage to the failure of immune surveillance and the subsequent uncontrolled proliferation of cancer cells.