pH Assist Pro App – 1-year License

pH Assist Pro™ App – 1 Year License

Predict the pH of a pharmaceutical solution from the API, its impurities, its degradation products and its buffer, before you prepare it.

ACCESS pH Assist Pro™

1. Follow the link: https://ph-assist-pro.vercel.app

2. Enter the access key provided with your purchase.

(This grants you a full 12 months of access to the application).

Description

Your impurity limit is not your pH limit.

Procaine hydrochloride, 20 mg/mL in water, has a pH of 5.83. Let 2 % of it hydrolyse and the pH is 4.66. The API barely changed. Its degradant, 4-aminobenzoic acid, took control of the pH from 11 µM, 0.0077 % of the API, far below any impurity limit.

The pH of a solution is not the pKa of the API. It is the one value at which every equilibrium in the flask agrees: the API, its counter-ion, every impurity and degradant, the buffer and water. pH Assist Pro solves all of them at once.

HOW IT WORKS

1. Type the API. The structure, molecular weight and every published pKa are read live from PubChem, each with its source. ChEMBL predictions are labelled as predictions.
2. See its degradation products. Curated pharmacopoeial routes for common APIs; for any other API, hydrolysis and oxidation products are predicted from the structure and identified in PubChem.
3. Get the pH. Mass and charge balance, Davies activity coefficients, pKa and Kw corrected for temperature — the pH a calibrated glass electrode reads, with the state of every component.
4. Find the impurities that matter. Each one is removed in turn: the pH shift it causes and the critical level at which it would move your pH by your threshold.
5. Decide. Sensitivity and model uncertainty, acid or base needed for a target pH, the calibration buffers to use, and a measured-vs-predicted check.
6. File it. An A4 report you can print or save as PDF.

WHO IT IS FOR

Formulation scientists, analytical chemists and QC analysts who set or justify pH specifications, run stability and forced degradation studies, choose buffers, or investigate an unexpected pH result.

VERIFIED

Checked against the NIST / IUPAC primary pH standards: seven of seven within ±0.02 pH.

The one exception is shown openly,alcium hydroxide, where ion pairing matters.

WHAT YOU GET

• A one-year licence to pH Assist Pro, a web app: nothing to install, runs in Chrome, Edge, Firefox or Safari
• Activates on two devices, one at a time, a lab PC and a laptop, say
• The Professional User Guide (Word): every screen explained, a fully worked example and troubleshooting
• The Welcome & Access sheet with your app address and three steps to get in
• A sample report, so you can see the output before you run anything

YOUR DATA STAYS WITH YOU

Your formulations are saved in your own browser. Nothing is uploaded.

Only the compound name you search for is sent to PubChem.

SCOPE

pH Assist Pro is a scientific decision-support tool. It is not a validated computerised system, it does not create a GxP record, and it is not a system of record.

A predicted pH supports, and does not replace, measurement of the prepared solution with a calibrated pH meter.

Licensed per user.

Created by Mirela Gorjanu, MSc - Practical Pharma Science™. Buying for your lab or company?

Pay by card or PayPal and download a PDF invoice with your company name and VAT/tax number from your receipt. Need an invoice before you pay, a purchase-order reference, or licences for 5 or 10 analysts? Email practicalpharma.science@yahoo.com with your company name, billing contact and number of users, and you'll receive a quote within one business day.