EQD2 Dose Converter (Python Script) — Convert RTDOSE to EQD2 Directly from DICOM

RTDOSE → EQD2 Conversion Tool (Global & OAR-Specific α/β)

Convert RTDOSE → EQD2 in seconds with this Python-based, fully DICOM-native tool.

This script provides a TPS-independent workflow for computing biologically equivalent dose (EQD2) distributions directly from DICOM RTDOSE files — with support for both global and organ-specific α/β values.

Whether you’re validating radiobiological models, performing independent dose checks, or building automation workflows, this tool generates clean, import-ready EQD2 RTDOSE files that can be viewed in any DICOM-compliant system.

✨ Key Features

✔️ Fully DICOM-native implementation (pydicom — no TPS required)

✔️ Voxel-by-voxel RTDOSE → EQD2 conversion using the linear-quadratic model

✔️ Global EQD2 calculation using a single α/β value applied to the entire dose grid

✔️ OAR-specific α/β overrides

    • Apply different α/β values inside selected organs at risk

    • Retain the global α/β everywhere else

✔️ Generates multiple EQD2 dose series for direct comparison:

    • Original physical dose

    • EQD2 (global α/β only)

    • EQD2 (with OAR-specific α/β overrides)

✔️ Automatic DoseGridScaling calculation for safe DICOM export

✔️ Preserves FrameOfReferenceUID for correct CT/dose alignment

✔️ Generates new DICOM UIDs for clean import into any system

✔️ Removes ReferencedRTPlanSequence so the dose is treated as an evaluation dose

✔️ Produces RTDOSE files compatible with all DICOM-compliant TPS, PACS, and viewers

✔️ Clean, well-commented Python code — easy to customize for research or clinical workflows

🎯 Perfect For

• Medical physicists

• Radiobiology researchers

• DICOM developers

• Automation and scripting engineers

• Anyone needing biological dose visualization outside the TPS