Antibiotic Safety in Ehlers Danlos Syndrome (EDS), Dysautonomia/ POTS, and Mast Cell Activation Syndrome (MCAS)
Antibiotic Safety in Ehlers-Danlos Syndrome (EDS), Dysautonomia/POTS, and Mast Cell Activation Syndrome (MCAS)
A Living Signal Research Evidence-Based Doctor Handout
Purpose:
To help patients and doctors recognize the serious risks certain antibiotic families pose for people with connective tissue and autonomic disorders and to bring clear, peer-reviewed science into the conversation before harm happens.
Overview:
For many with EDS, POTS, or MCAS, a simple course of antibiotics can trigger severe flares, nerve pain, or long term tissue damage. Fluoroquinolones, like Cipro and Levaquin, are among the most dangerous for this community, linked in FDA warnings and multiple studies to collagen breakdown, mitochondrial toxicity, and vascular injury. Most doctors never realize the connection.
Inside This Handout:
- 🔹 Complete list of every fluoroquinolone generation and brand name
- 🔹 Mechanisms explaining tendon, vascular, and mitochondrial injury
- 🔹 Evidence on cross reactivity and long term side effects
- 🔹 Safer antibiotic families (when clinically appropriate)
- 🔹 Chart documentation language to protect future care
- 🔹 Fully cited with peer-reviewed and FDA references
This 8 page PDF bridges patient experience and medical research giving you credible, evidence-based language to start safer prescribing conversations with your doctor.
