NSAID Sensitivity in Ehlers Danlos Syndrome and Mast Cell Activation Syndrome

NSAID Sensitivity in Ehlers Danlos Syndrome (EDS) and Mast Cell Activation Syndrome (MCAS)

A Living Signal Research Evidence Based Doctor Handout

Many people with EDS and MCAS experience unexpected or severe reactions to common pain relievers, yet few providers understand why. This evidence based handout explains the science behind NSAID hypersensitivity, linking mast cell activation, connective tissue fragility, and autonomic instability.

Designed for both patients and clinicians, this concise 3-page summary brings peer-reviewed immunology and pharmacology research into everyday practice, helping prevent harmful medication reactions and improve pain-management discussions.

Inside This Handout:

• Mechanisms of NSAID-induced mast cell activation and “pseudoallergic” reactions
• Why EDS patients are at higher risk for vascular and autonomic complications
• Common symptoms and patterns seen in MCAS/EDS reactions
• Evidence based alternatives and safer pain management options
• Clinical documentation phrasing and terminology for accurate records
• Fully cited with FDA and peer-reviewed medical references

Who It’s For:

• Patients with EDS, POTS, or MCAS managing chronic pain or medication reactions
• Clinicians and pharmacists seeking credible, cited guidance
• Advocates and caregivers supporting safer prescribing conversations

Format:

• 3 page printable PDF (8.5x11")
• Professionally formatted and fully citation-supported
• Ideal for sharing in clinical appointments or keeping in your medical binder