The Practical HPLC Chromatogram Troubleshooting Atlas

The Practical HPLC Chromatogram Troubleshooting Atlas

Author: Mirela Gorjanu

Publisher: Practical Pharma Science

An outstanding practical reference for anyone working in pharmaceutical HPLC. The visual case-based approach makes troubleshooting intuitive, and every problem includes logical diagnostic steps, confirmations, corrective actions, and prevention strategies. Unlike traditional textbooks, this atlas is designed for use at the laboratory bench, making it an excellent resource for QC analysts, method development scientists, validation teams, and students. Highly recommended.

Why it deserves 5 stars

• The concept is highly original: a visual troubleshooting atlas organized by chromatographic symptom rather than theory, making it ideal for real laboratory use.
• Every case follows the same structured workflow - What You Observe → Possible Causes → How to Confirm → Corrective Actions → Prevention → Technical Note - which is exactly how experienced chromatographers troubleshoot.
• The infographic pages are exceptionally well designed. Cases such as Peak Tailing, Peak Fronting, Peak Splitting, and Retention Drift communicate complex concepts in seconds while remaining technically meaningful.
• The atlas covers the major troubleshooting domains including peak shape, retention, resolution, baseline problems, ghost peaks, injection issues, pump/mobile phase problems, column problems, detector problems, and method development.
• The content is consistently aligned with current pharmaceutical practice, citing ICH Q2(R2), ICH Q14, and USP <621> throughout.