HPLC Method Review & Optimizer Pro App – 1-year License

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HPLC Method Review & Optimizer Pro App: 1-Year Licence

Your critical pair won't resolve. Find out why before you change anything.

A chromatogram tells you something is wrong. It rarely tells you why. Co-elution, a tailing API, a first peak sitting near the void: each has a different cause, and each needs a different fix. Change %B when the real problem is pH sitting on a pKa, and you have spent a day of instrument time learning nothing.

HPLC Method Review & Optimizer Pro reviews your chromatogram, diagnoses the method behind it and simulates the experiments most likely to fix it. All of this happens before you inject.

ACCESS HPLC Method Review & Optimizer Pro™

1.Follow the link: https://hplc-method-review-optimizer-pro.vercel.app

2. Enter the access key provided with your purchase.

(This grants you a full 12 months of access to the application).

Start with whatever data you have

An image or a PDF page from your data system, reviewed qualitatively and labelled clearly as an estimate
A peak table (retention time, width, tailing, area) for full quantitative review
The raw detector trace as a CSV or TXT file, which adds signal-to-noise, baseline noise, drift and shoulder detection

The app never reports more precision than your data supports.

What you get

Chromatogram review: retention factor, selectivity, resolution, plate count, USP tailing and signal-to-noise for every peak, calculated with the pharmacopoeial equations
What could be improved: every deficiency ranked by severity, with the variable that fixes it and the chromatographic reason why
Method review: eight systematic checks, covering stationary phase, pH against pKa and buffer capacity, organic modifier, gradient steepness, flow and pressure, temperature, injection solvent and detection
Method Improvement Simulator: a retention model calibrated to your measured peaks, showing the current and predicted chromatograms side by side, plus a live what-if for %B, pH, gradient time, flow, temperature, column length and particle size
Ranked experimental plan: single-factor experiments ranked against your own objectives (resolution, runtime, robustness, pressure, solvent use). Any change that would push a peak into the void or exceed the pressure limit is penalised.
Analytical Review Report: cover and document control, executive verdict, a system-suitability PASS/FAIL table, a sheet for each experiment with overlay chromatograms, prioritised recommendations and sign-off. Print it to PDF.

Why you can trust the numbers

A deterministic chromatography engine calculates every value, so the same input always gives the same result. The AI writes the interpretation and can never change a number.

What's included

A hosted web app: nothing to install, and it works in any modern browser
A 1-year licence for two devices, for example a lab PC and a laptop. You can move to a new computer at any time with "Use on another device".
A fully analysed worked example that is ready when you open the app
The Professional User Guide (18 pages) and a Welcome guide
Your data is analysed on the server and never stored

Who it is for

HPLC and UHPLC method developers, QC analysts troubleshooting an existing method, and anyone who has to justify the next experiment before running it.

Scope

This is a scientific decision-support tool. It is not a validated computerised system, it does not create a controlled GxP record, and it is not a system of record. Predictions show the direction and approximate size of a change. Confirm every change experimentally on your own instrument.

Buying for your lab or company?

Pay by card or PayPal and download a PDF invoice with your company name and VAT/tax number from your receipt. Need an invoice before you pay, a purchase-order reference, or licences for 5 or 10 analysts? Email practicalpharma.science@yahoo.com with your company name, billing contact and number of users, and you'll receive a quote within one business day.

HPLC, LCMS & GCMS Apps Suite Presentation

👉 https://pps-app-suite.vercel.app/